Melanotan II (MT-2): Broad-Spectrum Melanocortin Agonism
Melanotan II (MT-2) is a synthetic cyclic heptapeptide analogue of alpha-melanocyte-stimulating hormone (Ī±-MSH). It was developed as a second-generation melanocortin receptor agonist with broader receptor affinity than MT-1 and has been extensively studied in preclinical research models.
Mechanisms of Action
MT-2 acts on multiple melanocortin receptors (MC1R, MC3R, MC4R, MC5R) with notable affinity for MC4R, which is involved in appetite and metabolic regulation. Preclinical research has characterized its receptor activity and downstream signaling, with published studies reporting on melanogenesis, energy-homeostasis, and melanocortin-linked behavioral endpoints in animal models. Studies have also investigated its pharmacokinetic profile, which differs from MT-1 due to its cyclic structure and extended receptor binding profile.
*For laboratory and research purposes only. Not for human or animal consumption.*
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