Melanotan I (MT-1) and Melanocortin Receptor Signaling

Melanotan I (MT-1) is a synthetic linear peptide analogue of alpha-melanocyte-stimulating hormone (α-MSH). It was developed as a first-generation melanocortin receptor agonist and has been studied in preclinical and early clinical models for its interaction with melanocortin signaling pathways.

Mechanisms of Action

MT-1 acts primarily on melanocortin 1 receptor (MC1R), stimulating melanogenesis in melanocytes. Preclinical research has examined its effects on melanogenesis pathways and its interaction with UV radiation exposure models. Early-phase clinical studies investigated melanin production endpoints in response to MT-1. Research has also characterized its binding affinity profile across the broader melanocortin receptor family (MC1-5R).

*For laboratory and research purposes only. Not for human or animal consumption.*

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